Metal injection molding of gas- and water-atomized Co-28Cr6Mo powders is evaluated. Sintering is conducted in different atmospheres to evaluate their effects on sintering response and carbon, nitrogen, and oxygen contents. The effects of hot isostatic pressing and heat treat on the mechanical properties are investigated. Properties are correlated to the interstitial content and microstructure. Optimized processing gives mechanical properties that exceed ASTM requirements for cast and wrought Co-28Cr-6Mo.